Purinergics

2-Methylthio-ADP trisodium salt
A potent purinergic agonist for the receptors P2Y1, P2Y12 and P2Y13 and a platelet aggregating agent. In addition, studies show that 2-Methylthio-ADP trisodium salt functions better as a human platelet adenylate cyclase inhibitor than a platelet aggregator.
カタログ # CAS Number Molecular Formula Unit
sc-203464 34983-48-7 C₁₁H₁₄N₅Na₃O₁₀P₂S 10 mg
2-Methylthioadenosine 5'-monophosphate triethylammonium salt hydrate
The only known preferential antagonist for the P2Y(AC) receptor. The platelet ADP receptor that is coupled to adenyl cyclase and is also referred to as the P2Y ADP receptor.
カタログ # CAS Number Molecular Formula Unit
sc-213854 22140-20-1 (non-salt) C₁₁H₁₆N₅O₇PS ·xC₆H₁₅N ·yH₂O 5 mg
2-Methylthioadenosine Triphosphate Tetrasodium Salt
An ATP analog that induces aortic smooth muscle relaxation in rat (EC₅₀ = 240 nM).
カタログ # CAS Number Molecular Formula Unit
sc-202910 43170-89-4 C₁₁H₁₄N₅O₁₃P₃S ·4Na 10 mg
2-ThioUTP tetrasodium salt
Potent and selective P2Y2 agonist (EC₅₀ values are 0.035, 0.35 and 1.5 μM for hP2Y2, hP2Y4 and hP2Y6 receptors respectively).
カタログ # CAS Number Molecular Formula Unit
sc-203773 35763-29-2 C₉H₁₁N₂Na₄O₁₄P₃S 1 mg
5-BDBD
Potent P2X4 receptor antagonist. Has been shown to block P2X4-mediated currents in Chinese hamster ovary cells .
カタログ # CAS Number Molecular Formula Unit
sc-290784 768404-03-1 C₁₇H₁₁BrN₂O₂ 10 mg/50 mg
α,β-Methyleneadenosine 5'-triphosphate lithium salt
P2 purinoceptor agonist which is more potent than ATP at the P2X subtype.
カタログ # CAS Number Molecular Formula Unit
sc-257039 104809-20-3 C₁₁H₁₈N₅O₁₂P₃•xLi+ 5 mg/10 mg
7-(2,3-Dihydroxypropyl)theophylline
カタログ # CAS Number Molecular Formula Unit
sc-357961 479-18-5 C₁₀H₁₄N₄O₄ 100 g/500 g
9-Methyluric acid
カタログ # CAS Number Molecular Formula Unit
sc-362184 55441-71-9 C₆H₆N₄O₃ 50 mg
α,β-Methyleneadenosine 5'-triphosphate trisodium salt
P2-purinoceptor agonist. Also shown to inhibit adenylate cyclase (Ki = 0.5 μM).
カタログ # CAS Number Molecular Formula Unit
sc-204428 7292-42-4 C₁₁H₁₅N₅Na₃O₁₂P₃ 10 mg
A 438079 hydrochloride
A competitive P2X7 receptor antagonist that does not substantially affect the activity of other P2 receptors.
カタログ # CAS Number Molecular Formula Unit
sc-203788 899507-36-9 C₁₃H₉Cl₂N₅•HCl 10 mg/50 mg
A 740003
A competitive antagonist of P2X7 receptors that has been shown to potently block proinflammatory cytokine IL-1β.
カタログ # CAS Number Molecular Formula Unit
sc-291774 861393-28-4 C₂₆H₃₀N₆O₃ 10 mg/50 mg
AR-C 66096 tetrasodium salt
カタログ # CAS Number Molecular Formula Unit
sc-361107 145783-24-0 C₁₄H₁₈F₂N₅Na₄O₁₂P₃S 1 mg
AZ 10606120 dihydrochloride
カタログ # CAS Number Molecular Formula Unit
sc-361113 N/A C₂₅H₃₄N₄O₂.2HCl 10 mg/50 mg
BzATP triethylammonium salt
Prototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC₅₀ = 0.7 μM in HEK 293 cells). Exhibits partial agonist activity at P2X1 (pEC₅₀ = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.
カタログ # CAS Number Molecular Formula Unit
sc-203862 112898-15-4 C₂₄H₂₄N₅O₁₅P₃ ·C₁₈H₄₅N₃ 1 mg
Chloro-IB-MECA
A3 adenosine receptor agonist.
カタログ # CAS Number Molecular Formula Unit
sc-257229 163042-96-4 N/A 5 mg
(±)-Clopidogrel hydrochloride
A thienopyridine adenosine diphosphate (ADP)-receptor antagonist, which functions as a selective irreversible P2Y12 receptor antagonist.
カタログ # CAS Number Molecular Formula Unit
sc-203553 90055-48-4 C₁₆H₁₆NO₂SCl.HCl 10 mg/50 mg
Cytidine 5'-triphosphate disodium salt
A P2X purinergic receptor agonist.
カタログ # CAS Number Molecular Formula Unit
sc-217995 36051-68-0 C₉H₁₄N₃Na₂O₁₄P₃ 500 mg/1 g
GW 791343 hydrochloride
P2X7 allosteric modulator. Exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). A positive allosteric modulator of rat P2X7.
カタログ # CAS Number Molecular Formula Unit
sc-203992 1019779-04-4 C₂₀H₂₄F₂N₄O ·3HCl 10 mg/50 mg
iso-PPADS tetrasodium salt
P2X-purinoceptor antagonist (pKi = 6.5) displaying similar activity to PPADS (sc-202770).
カタログ # CAS Number Molecular Formula Unit
sc-204019 N/A C₁₄H₁₀N₃Na₄O₁₂PS₂ 10 mg/50 mg
MRS 2179 tetrasodium salt
カタログ # CAS Number Molecular Formula Unit
sc-361263 101204-49-3 C₁₁H₁₃N₅O₉P₂Na₄ 10 mg/50 mg
MRS 2211
A selective and competitive P2Y13 receptor antagonist.
カタログ # CAS Number Molecular Formula Unit
sc-204101 N/A C₁₄H₁₀N₄O₈Na₂PCl•xNaCl•xNaOH•xH₂O 10 mg/50 mg
MRS 2219
Cyclic pyridoxine-alpha4, 5-monophosphate, compound. Selective potentiator of ATP-evoked responses at rat P2X1 receptors (EC₅₀0 = 5.9 µM).
カタログ # CAS Number Molecular Formula Unit
sc-204102 14141-47-0 C₈H₁₀NO₅P 10 mg/50 mg
MRS 2279
カタログ # CAS Number Molecular Formula Unit
sc-361264 367909-40-8 C₁₃H₁₈ClN₅O₈P₂.2NH₃ 1 mg
MRS 2365
カタログ # CAS Number Molecular Formula Unit
sc-361265 436847-09-5 C₁₃H₁₆N₅O₉P₂SNa₃ 1 mg
MRS 2500 tetraammonium salt
カタログ # CAS Number Molecular Formula Unit
sc-361266 779323-43-2 C₁₃H₁₈N₅O₈P₂I.4NH₃ 1 mg
MRS 2578
A symmetric aryl diisothiocyanate derivative that is shown to inhibit P2Y receptors. P2Y receptors are G-coupled receptors that are ATP activated and initiate an intracellular chain of reactions.
カタログ # CAS Number Molecular Formula Unit
sc-204103 711019-86-2 C₂₀H₂₀N₆S₄•2C₂H₆OS 10 mg/50 mg
MRS 2690
Potent P2Y14 receptor agonist (EC₅₀ = 49 nM) that displays 7-fold higher potency than UDP-glucose.
カタログ # CAS Number Molecular Formula Unit
sc-204104 N/A C₁₅H₂₂N₂Na₂O₁₆P₂S 1 mg
MRS 2693 trisodium salt
MRS2693 trisodium salt is a selective P2Y6 agonist which is reported to display no activity at other P2Y subtypes.
カタログ # CAS Number Molecular Formula Unit
sc-358788 911391-37-2 C₉H₁₀IN₂Na₃O₁₂P₂ 1 mg
MRS 2768 tetrasodium salt
A selective P2Y2 agonist.
カタログ # CAS Number Molecular Formula Unit
sc-311440 1047980-83-5 C₁₅H₁₆N₂O₁₈P₄Na₄ 1 mg
NF 023
A subtype selective, competitive and reversible P2X1 receptor antagonist. Displays IC₅₀ values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α-subunit of Go/i (EC₅₀ ~ 300 nM).
カタログ # CAS Number Molecular Formula Unit
sc-204124 104869-31-0 C₃₅H₂₀Na₆N₄O₂₁S₆ 10 mg/50 mg
NF 023 hydrate
This is a potent, selective P2X1 purinoceptor antagonist.
カタログ # CAS Number Molecular Formula Unit
sc-257898 104869-31-0 (anhydrous) C₃₅H₂₀N₄O₂₁S₆ ·6Na ·xH₂O 10 mg
NF 110
Potent P2X3 receptor antagonist. Also exhibits anti-tumor activity in several tumor types.
カタログ # CAS Number Molecular Formula Unit
sc-203642 111150-22-2 C₄₁H₂₈N₆Na₄O₁₇S₄•xH₂O 10 mg/50 mg
NF 157
カタログ # CAS Number Molecular Formula Unit
sc-204125 104869-26-3 C₄₉H₂₈F₂N₆Na₆O₂₃S₆ 10 mg/50 mg
NF 279
Suramin analog that is a highly selective, competitive, and reversible ATP-antagonist of P2X receptor. Effectively discriminates between P2Y and P2X receptors.
カタログ # CAS Number Molecular Formula Unit
sc-202730 202983-32-2 C₄₉H₃₀N₆O₂₃S₆ ·6Na 5 mg
NF 546
カタログ # CAS Number Molecular Formula Unit
sc-361275 N/A C₄₇H₄₄N₆Na₄O₁₇P₄ 10 mg/50 mg
PIT
Purinergic P2Y receptor ligand. Displays mixed antagonism at P2Y receptors in some smooth muscles but potentiates responses to ATP in other systems (chick brain recombinant P2Y1 receptor and sympathetic/purinergic nerve stimulation).
カタログ # CAS Number Molecular Formula Unit
sc-203665 56583-49-4 C₁₃H₈N₂O₂.C₇H₈O₃S 10 mg/50 mg
PPADS tetrasodium salt
Non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5, native P2Y2-like, and recombinant P2Y4 receptors.
カタログ # CAS Number Molecular Formula Unit
sc-202770 149017-66-3 C₁₄H₁₀N₃Na₄O₁₂PS₂ 10 mg/50 mg
PPNDS
Potent and selective P2X1 receptor antagonist (pKB = 7.43 in rat vas deferens). Up to 52-fold selective over P2Y1 receptors, and selective over α1A-adrenoceptors, A1, A2B, ecto-nucleotidase, H1, M3 receptors.
カタログ # CAS Number Molecular Formula Unit
sc-204211 N/A C₁₈H₁₁N₄Na₄O₁₄PS₂ 10 mg/50 mg
PSB 0474
Potent and selective P2Y6 receptor agonist (EC₅₀ values are 7, > 1000 and > 10000 nM for P2Y6, P2Y2 and P2Y4 receptors respectively).
カタログ # CAS Number Molecular Formula Unit
sc-203668 917567-60-3 C₁₇H₁₈N₂Na₂O₁₃P₂ 1 mg
Ro 0437626
Selective P2X1 purinergic receptor antagonist (IC₅₀ = 3 μM) that displays > 30-fold selectivity over P2X2, P2X3 and P2X2/3 receptors (IC₅₀ > 100 μM).
カタログ # CAS Number Molecular Formula Unit
sc-204239 134362-79-1 C₂₇H₃₅N₅O₄S 1 mg/10 mg
RO-3
Selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC₅₀ values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC₅₀ > 10 μM). Attenuates nociceptive sensitivity in animal models of pain. Orally active and brain penetrant.
カタログ # CAS Number Molecular Formula Unit
sc-204242 N/A C₁₆H₂₂N₄O₂ 10 mg
TNP-ATP triethylammonium salt
A selective P2X receptor antagonist which inhibits ATP-induced currents in cells, specifically P2X1, P2X3 and heteromeric P2X2/3 receptors.
カタログ # CAS Number Molecular Formula Unit
sc-204348 61368-63-6 C₁₆H₁₃N₈O₁₉P₃•C₂₄H₆₄N₄ 5 mg
UDP disodium salt
An endogenous P2Y receptor agonist, which specifically activates P2Y6 receptors.
カタログ # CAS Number Molecular Formula Unit
sc-204372 27821-45-0 C₉H₁₂N₂Na₂O₁₂P₂•xH₂O 50 mg
Uridine 5'-diphosphate sodium salt from Saccharomyces cerevisiae
A P2Y receptor agonist.
カタログ # CAS Number Molecular Formula Unit
sc-222401 21931-53-3 C₉H₁₄N₂O₁₂P₂•xNa 25 mg/100 mg
Uridine 5'-triphosphate tris salt
An agonist to the P2Y receptor.
カタログ # CAS Number Molecular Formula Unit
sc-213136 108321-53-5 C₉H₁₅N₂O₁₅P₃ 100 mg/500mg
Uridine 5'-triphosphate trisodium salt dihydrate
An agonist of the P2Y receptor.
カタログ # CAS Number Molecular Formula Unit
sc-213137 116295-90-0 C₉H₁₆N₂Na₃O₁₇P₃ 250 mg
UTPγS trisodium salt
Enzymatically stable, selective P2Y2 and P2Y4 receptor agonist.
カタログ # CAS Number Molecular Formula Unit
sc-204376 N/A C₉H₁₂N₂Na₃O₁₄P₃S 1 mg