S-100A14 Background Information
The S-100 protein family consists of a group of calcium-binding proteins, which exhibit cell and tissue-specific expression. The expression levels of its members differ in various pathological conditions. The extracellular functions of the S-100 family may include the ability to enhance neurite outgrowth, involvement in inflammation, and motility of tumor cells. S100 calcium binding protein A14 (S-100A14), a member of the S-100 protein family, is expressed highest in the colon and moderately in the thymus, kidney, liver, small intestine, and lung. Low expression of S-100A14 is observed in the heart, while no detection is seen in brain, skeletal muscle, spleen, placenta and peripheral blood leukocytes. S-100A14 is a 104-amino acid protein that is 68% homologous to the S-100A13 protein. It contains 2 EF-hand Ca2+-binding domains, a myristoylation motif, a glycosylation site, and several potential protein kinase phosphorylation sites.
