epitope mapping within an internal region of ACOT7 of human origin
recommended for detection of ACOT7 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
ACOT7 Background Information Acyl-CoA thioesterases (ACOTs) are a group of enzymes that catalyze the hydrolysis of acyl-CoA to form coenzyme A (CoA) and a free fatty acid. Through their catalytic activity, ACOTs are able to regulate the level of fatty acids and acyl-CoAs within the cell. ACOT7 (acyl-CoA thioesterase 7), also known as BACH (brain acyl-CoA hydrolase), LACH or CTE-II, is a 380 amino acid protein that is expressed as 6 alternatively spliced isoforms which localize to either the cytoplasm or the mitochondria. Functioning as a homodimer that contains 2 acyl coenzyme A hydrolase domains, ACOT7 plays an important role in regulating acyl-CoA levels within the body and is thought to specifically participate in proper brain physiology and function. Decreased ACOT7 expression may be associated with mesial temporal lobe epilepsy, a form of focal epilepsy that is characterized by simple or complex seizures.
