epitope mapping within an internal region of MRP-S11 of human origin
recommended for detection of MRP-S11 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with MRP-S11-3; also reactive with additional species, including equine, canine and bovine
MRP-S11 Background Information Mitochondrial ribosomes consist of a large 39S subunit and a small 28S subunit, both of which are comprised of multiple mitochondrial ribosomal proteins (MRPs) that are encoded by nuclear genes and are essential for protein synthesis within mitochondria. MRP-S11 (mitochondrial ribosomal protein S11) also known as Cervical cancer proto-oncogene 2 protein, is a 194 amino acid protein that localizes to the mitochondrion, where it exists as a component of the 28S ribosomal subunit and works in conjunction with other MRPs to mediate protein synthesis. Mutations in the MRP-S16 and MRP-S22 genes also cause a loss of MRP-S11 expression. The phenotype of these gene mutations is severe fatal respiratory chain dysfunction due to impaired translation of mitochondrial mRNAs. There are three isoforms of MRP-S11 that are produced as a result of alternative splicing events.
