VAT1 (G-12) 抗体: sc-107348

VAT1 Background Information
The storage and release of neurotransmitters in the nerve terminal is regulated by synaptic vesicles. In response to an intracellular increase in calicum levels, synaptic vesicles open and release neurotransmitters across the neuronal synapse, thereby propagating nerve impulses between neurons. VAT1 (vesicle amine transport protein 1) is a 393 amino acid integral membrane protein that is located within cholinergic synaptic vesicles. Expressed in tissues throughout the body, VAT1 belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins and is thought to play a role in vesicular transport. Defects in the gene encoding VAT1 may be associated with endocrine disorders and tumorigenesis.