epitope mapping within an internal region of WFDC1 of human origin
recommended for detection of WFDC1 of mouse, rat and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
WFDC1 Background Information The WAP domain (also referred to as the WAP-type four-disulfide core domain), is a signature protein motif that contains eight cysteine residues which form disulfide bonds and may exhibit protease inhibitor activity. WFDC1 (WAP four-disulfide core domain 1), also known as PS20, is a 220 amino acid secreted protein that contains one WAP domain and is thought to possess growth inhibitory activity. The gene encoding WFDC1 maps to a region on human chromosome 16 that is often lost or mutated in several cancers, including breast, prostate and hepatocellular carcinomas, suggesting a role for native WFDC1 in tumor suppression. Human chromosome 16, on which the WFDC1 gene is located, encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition.
