TAL1 Background Information Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.
TAL1 (E-14): sc-12982. Western blot analysis of TAL1 expression in NIH/3T3 nuclear extract.
TAL1 (E-14): sc-12982. Western blot analysis of TAL1 expression in non-transfected: sc-117752 (A) and human TAL1 transfected: sc-172270 (B) 293T whole cell lysates.
