UBE2F Background Information Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBE2F (ubiquitin-conjugating enzyme E2F), also known as NCE2, is a 185 amino acid protein that belongs to the E2 family of ubiquitin conjugating enzymes. UBE2F functions to accept the ubiquitin-like protein NEDD8 from an E1 complex and to catalyze the ATP-dependent attachment of NEDD8 to other proteins, playing a role in the pathway of protein degradation. The gene encoding UBE2F maps to chromosome 2, which encodes over 1,400 genes and comprises nearly 8% of the human genome.
UBE2F (C-23)
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UBE2F (C-23): sc-130284. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cancer tissue showing cytoplasmic staining.
UBE2F (C-23): sc-130284. Western blot analysis of UBE2F expression in Jurkat whole cell lysate.
UBE2F (C-23): sc-130284. Western blot analysis of UBE2F expression in non-transfected: sc-110760 (A) and human UBE2F transfected: sc-112735 (B) 293 whole cell lysates.
