MAGE-D2 (FW.6) 抗体: sc-130443

MAGE-D2 Background Information
The melanoma-associated antigen (MAGE) family consists of a number of antigens recognized by cytotoxic T lymphocytes. The MAGE genes were initially isolated from different kinds of tumors and, based on their virtually exclusive tumor-specific expression in adult tissues, they have been used as targets for cancer immunotherapy. MAGE genes encode for tumor-rejection antigens that are expressed in tumors of different histologic types and in normal testis and placenta. MAGE-D2 (Melanoma-associated antigen D2), also known as BCG1 (Breast cancer-associated gene 1), 11B6, HCA10 or JCL-1, is a 606 amino acid protein that contains one MAGE domain. Expressed throughout the body, MAGE-D2 is thought to function as a negative regulator of p53 (a potent tumor suppressor), possibly contributing to tumor formation and metastasis. Multiple isoforms of MAGE-D2 exist due to alternative splicing events.