epitope mapping within an internal region of S-100A3 of human origin
recommended for detection of S-100A3 of mouse, rat and human origin by WB, IF and ELISA; non cross-reactive with other S-100 family members; also reactive with additional species, including canine and porcine
S-100A3 Background Information The S-100 protein family consists of a group of calcium-binding proteins that are exclusively expressed in vertebrates and exhibit cell and tissue-specific expression. The expression levels of its members differ in various pathological conditions. The extracellular functions of the S-100 family may include the ability to enhance neurite outgrowth, involvement in inflammation and motility of tumor cells. S-100A3 (S100 calcium binding protein A3), also known as S100E, is a 101 amino acid cysteine-rich protein that belongs to the S-100 family of proteins. Expressed specifically at the inner endocuticle of hair fibers, S-100A3 contains two EF-hand domains and exists as a multimer. S-100A3 binds calcium with low affinity and zinc with high affinity and is believed to play a role in the calcium-dependent differentiation of cuticle cells and in the formation of hair shafts.
