ALOXE3 Background Information ALOXE3 (arachidonate lipoxygenase 3), also known as E-LOX or eLOX3, is a 711 amino acid protein that is involved in lipid metabolism and contains one lipoxygenase domain and one PLAT domain. Expressed predominately in skin, ALOXE3 uses iron as a cofactor to introduce oxygen into polyunsaturated fatty acids and is thought to play an important role in the catabolism of leukotrienes (arachidonic acid-derived compounds which participate in inflammation and hypersensitivity). Defects in the gene encoding ALOXE3 are the cause of non-bullous congenital ichthyosiform erythroderma (NCIE), a skin disorder characterized by an abnormal cornification of the epidermis, with symptoms including scaling and red skin, as well as painful fissures resulting from palmoplantar keratoderma.
