LASS3 Background Information The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6) and they are all involved in sphingolipid synthesis. LASS3 is a 383 amino acid membrane protein almost exclusively expressed in testis, suggesting that LASS3 plays an important role in proper testis function. It is also weakly expressed in skin. A transcriptional variant of LASS3 cDNA exists and can result in the production of a 419 amino acid protein (LASS3-long). LASS3 overproduction raises the level of several ceramide species, including C18:0- and C24:0-ceramides.
LASS3 (O-25)
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LASS3 (O-25): sc-133725. Western blot analysis of LASS3 expression in Jurkat nuclear extract.
LASS3 (O-25): sc-133725. Western blot analysis of LASS3 expression in human fetal liver tissue extract.
LASS3 (O-25): sc-133725. Western blot analysis of LASS3 expression in HeLa nuclear extract.
