PAGE-1 Background Information
PAGE-1 (P antigen family, member 1), also known as CT16.3, GAGE-9 or GAGEB1, is a 146 amino acid protein that may play a role in tumor formation and metastasis and is encoded by a gene which maps to human chromosome X. Chromosome X, one of the two human sex chromosomes, contains nearly 153 million base pairs and encodes over 1,000 genes. In conjunction with chromosome Y, chromosome X is responsible for sex determination, as an X and a Y chromosome lead to normal male development, while two copies of an X chromosome lead to normal female development. There are a number of conditions related to an abnormal number and combination of sex chromosomes, some of which include Turner's syndrome, color blindness, hemophilia and Duchenne muscular dystrophy.
