pan ECA (MECA-32) 抗体: sc-19603

pan ECA Background Information
The vascular network is a highly branched closed circuit of blood vessels, which extends throughout the body and mediates the delivery and exchange of blood. Blood vessels consist of an endothelium, which is a continuous, cylindrical epithelial cell layer, a basal lamina, and an outer mural cell layer. In addition to blood vessels, endothelial cells line the interiors of tissue cavities and spaces. MECA-32 is a mouse monoclonal antibody that shows high specificity for mouse endothelium in both embryonic and mature tissues. The MECA-32 antigen is expressed on most endothelial cells of the embryonic and adult mouse, with the exception of brain, skeletal, and cardiac muscle. In skeletal and cardiac muscle, small arterioles and venules express the MECA-32 antigen. In the brain, MECA-32 expression negatively correlates with the differentiation of the vasculature to form the blood brain barrier.