Rab 2B (I-12) 抗体: sc-26550

Rab 2B Background Information
The Ras-related superfamily of guanine nucleotide binding proteins includes the R-Ras, Rap, Ral/Rec and Rho/Rab subfamilies all of which are thought to play an important role in either endocytosis or in biosynthetic protein transport. The process of transporting newly synthesized proteins from the endoplasmic reticulum (ER) to various stacks of the Golgi complex and to secretory vesicles involves the movement of carrier vesicles and requires Rab protein function. Rab proteins are also an integral part of endocytic pathways. Rab 2A (Ras-related protein Rab-2A) and Rab 2B (Ras-related protein Rab-2B) are 212 and 216 amino acid proteins, respectively, that belong to the Ras-related GTPase superfamily. While both Rab 2A and Rab 2B are required for protein transport from the ER to the Golgi, Rab 2A is lipid-anchored to the ER-Golgi intermediate compartment membrane while Rab 2B is lipid anchored to the cytoplasmic side of the cell membrane.