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p107 (C-18) 抗体: sc-318 |
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- rabbit polyclonal IgG, 200 µg/ml; also available as goat IgG, 200 µg/ml, sc-318-G
- epitope mapping at the C-terminus of p107 of human origin
- recommended for detection of p107 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
- blocking peptide, sc-318 P
- agarose conjugate for IP studies, sc-318 AC, 500 µg/0.25 ml agarose
- TransCruz reagent for Gel Supershift and ChIP applications, sc-318 X, 200 µg/0.1 ml
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p107 Background Information
The human retinoblastoma gene product plays an important role in the negative regulation of cell proliferation. Functional inactivation of Rb can be mediated either through mutation or as a consequence of interaction with DNA tumor virus encoded proteins. pRb and the structurally related p107 form complexes with E2F, a transcription factor originally identified through its role in transcriptional activation of the adenovirus E2 promoter. Moreover, pRB and p107 share a high degree of structural homology in the adenovirus E1A binding domain (i.e. “pocket region”) that is believed to play a primary role in the function of these proteins. A protein designated p130 shows a high degree of identity with pRb and p107 and also possesses a pocket region.
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他の研究者が、p107 (C-18): sc-318抗体およびp107 (C-18)のconjugate抗体をどのように使用したかを見る。
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p107 (C-18)
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p107 (C-18): sc-318. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human colon carcinoma tissue (A) showing nuclear localization. Immunofluorescence staining of methanol-fixed NIH/3T3 cells (B) showing nuclear localization.
p107 (C-18): sc-318-G. Western blot analysis of p107 expression in C32 (A), MM-142 (B) and KNRK (C) whole cell lysates. p107 (C-18): sc-318. Western blot analysis of p107 expression in SK-BR-3 (A), C32 (B), NIH/3T3 (C), MM-142 (D), KNRK (E) and 3611-RF (F) whole cell lysates.
p107 (C-18): sc-318. Western blot analysis of p107 expression in non-transfected 293T: sc-117752 (A), truncated human p107 transfected 293T: sc-114727 (B) and SK-BR-3 (C) whole cell lysates. p107 (C-18)-G: sc-318-G. Western blot analysis of p107 expression in non-transfected 293T: sc-117752 (A), truncated human p107 transfected 293T: sc-114727 (B) and SK-BR-3 (C) whole cell lysates. |
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