epitope mapping near the N-terminus of DHCR24 of human origin
recommended for detection of DHCR24 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
DHCR24 Background Information Dehydrocholesterol reductase (DHCR) proteins are involved in cholesterol bio-synthesis. DHCR7, also designated sterol Delta-7 reductase or 7-DHC reductase, reduces the C7-C8 double bond of 7-dehydrocholesterol. It is a multi-pass membrane protein localizing to the endoplasmic reticulum (ER). Defects in the DHCR7 gene can cause Smith-Lemli-Opitz syndrome (SLOS), an autosomal recessive disorder of sterol metabolism. DHCR24 acts as a catalyst for the reduction of the Delta-24 double bond of sterol intermediates. DHCR24, also designated 3-b-hydroxysterol Delta-24 reductase or seladin-1, binds to FAD and is predominantly expressed in adrenal gland and brain. It is a single-pass membrane protein localizing to the ER or Golgi apparatus. Defects in the DHCR24 gene cause cause the autosomal recessive disorder desmosterolosis.
DHCR24 (N-15)
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DHCR24 (N-15): sc-48475. Western blot analysis of DHCR24 expression in PC-12 (A) and A-375 (B) whole cell lysates.
DHCR24 (N-15): sc-48475. Western blot analysis of DHCR24 expression in non transfected (A) and human DHCR24 transfected (B) whole cell lysates.
