GPR30 (K-19)-R 抗体: sc-48524-R

GPR30 Background Information
G protein-coupled receptors (GPCRs), also designated seven transmembrane (7TM) receptors and heptahelical receptors, are a protein family which interact with G proteins (heterotrimeric GTPases) to synthesize intracellular second messengers such as diacylglycerol, cyclic AMP, inositol phosphates, and calcium ions. Their diverse biological functions range from vision and olfaction to neuronal and endocrine signaling and are involved in many pathological conditions. G protein receptor 30 (GPR30), also designated chemokine receptor-like 2 (CMKRL2), is a 375-amino acid protein orphan GCPR. GRP30 is an intracellular transmembrane estrogen receptor localized to the endoplasmic reticulum which binds estrogen and estrogen derivatives.