KCNA10 (N-16) 抗体: sc-54391

KCNA10 Background Information
KCNA10, also called cyclic GMP gated potassium channel, is a member of the shaker-related subfamily of the potassium voltage-gated channel family. This 511 amino acid multipass membrane protein acts as a potassium-selective channel through which potassium ions flow in accordance with their electrochemical gradient. KCNA10 is expressed in human proximal tubular cells, glomerular and vascular endothelial cells and vascular smooth muscle cells. KCNA10 takes on two conformations: the open conformation and closed conformation. These conformations are determined by the voltage difference across the plasma membrane. KCNA10 shares common traits with K-selective and cyclic-nucleotide-gated (CNG) cation channels. The C-terminus of KCNA10 may be involved in targeting the channel to specific subcellular compartments. The S4 segment of KCNA10 is anticipated to be the voltage sensor due to its high sequence similarity to other closely related channel proteins.