epitope mapping within an internal region of IDH3A of human origin
recommended for detection of IDH3A of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
IDH3A Background Information IDH3A (Isocitrate dehydrogenase [NAD] subunit a (mitochondrial), NAD(+)-specific ICDH) is a 366 amino acid protein encoded by the human gene IDH3A. IDH3A belongs to the isocitrate and isopropylmalate dehydrogenases family and can bind one magnesium or manganese ion per subunit. It is usually found in the mitochondrion as a heterooligomer of subunits a, b, and g in the apparent ratio of 2:1:1. Human NAD-dependent isocitrate dehydrogenase (IDH) is allosterically activated by ADP by lowering the Km for isocitrate. NAD-dependent isocitrate dehydrogenase is a tricarboxylic acid cycle enzyme that produces 2-oxoglutarate, an organic acid required by the glutamine synthetase/glutamate synthase cycle to assimilate ammonium.
IDH3A (E-20)
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IDH3A (E-20): sc-55670. Western blot analysis of IDH3A expression in rat skeletal muscle tissue extract.
