epitope corresponding to amino acids 144-182 mapping within an internal region of MacroH2A of human origin
recommended for detection of MacroH2A of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and bovine
TransCruz reagent for Gel Supershift and ChIP applications, sc-67322 X, 200 µg/0.1 ml
MacroH2A Background Information Eukaryotic histones are water soluble, basic nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer. The octamer consists of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. MacroH2A, also called core histone MacroH2A2 (mH2A2), is a variant Histone H2A, originally isolated in rat liver, that is nearly three times as large as conventional H2A. MacroH2A may be involved in stable X chromosome inactivation as it is enriched in inactive X chromosome chromatin.
MacroH2A (H-39)
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MacroH2A (H-39): sc-67322. Western blot analysis of human recombinant MacroH2A fusion protein.
MacroH2A (H-39): sc-67322. Western blot analysis of MacroH2A expression in human MacroH2A transfected: sc-111902 (A) and non-transfected: sc-110760 (B) 293 whole cell lysates.
