epitope mapping within an internal region of Codanin-1 of human origin
recommended for detection of Codanin-1 of mouse and human origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
Codanin-1 Background Information The congenital dyserythropoietic anemias (CDAs) are an uncommon and heterogeneous group of disorders that are characterized by markedly ineffective erythropoiesis and, usually, striking dysplastic changes in erythroblasts. Con-genital dyserythropoietic anemia type 1 (CDA1) is a rare autosomal recessive disorder with ineffective erythropoiesis, characteristic morphological abnormalities of erythroblasts and iron overloading. CDA1 is caused by mutations in the CDAN1 gene, which maps to chromosome 15q15.2 and encodes the 1,227 amino acid protein Codanin-1. Codanin-1 has a 150 residue N-terminal domain with sequence similarity to collagens and two shorter segments that show weak similarities to the microtubule-associated proteins synapsin and MAP-1B (neuraxin). Research indicates that Codanin-1 may be involved in nuclear envelope integrity, conceivably related to microtubule attachments. Skeletal anomalism has been associated with mutations of CDAN1, indicating that Codanin-1 may play a role in the development of the skeleton.
