ZNF161 Background Information Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF161, also called VEZF1 (vascular endothelial zinc finger 1) or DB1, is a nuclear localizing zinc-finger protein belonging to the Krüppel C2H2-type zinc-finger family. Expressed throughout the body with the highest level of expression found in the kidneys and skeletal muscle, ZNF161 is an endothelial transcription factor that regulates ET-1 (endothelin-1) promoter expression. Through its interaction with the CT/GC-rich region of the ET-1 promoter, ZNF161 helps to regulate proper assembly of the cardiovascular system during early development by activating the expression of various genes found in the vascular endothelium.
ZNF161 (ZNF5J141)
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ZNF161 (ZNF5J141): sc-81134 Western Blot analysis of human recombinant ZNF161 fusion protein.
ZNF161 (ZNF5J141): sc-81134 Western Blot analysis of ZNF161 expression in HeLa whole cell lysate.
ZNF161 (ZNF5J141): sc-81134 Western Blot analysis of ZNF161 expression in NIH/3T3 whole cell lysate.
ZNF161 (ZNF5J141): sc-81134 Western Blot analysis of ZNF161 expression in F2408 whole cell lysate.
