JMJD2A Background Information JMJD2A (jumonji domain containing 2A), also designated jumonji C domain-containing histone demethylation protein 3A, is a 1,064 amino acid protein encoded by the human gene JMJD2A. JMJD2A belongs to the JHDM3 histone demethylase family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers and two Tudor domains. JMJD2A is histone de-methylase that specifically demethylates Lys 9 and Lys 36 residues of Histone H3, thereby playing a central role in histone code. It does not demethylate histone H3 Lys 4, H3 Lys 27 nor H4 Lys 20, however, it will demethylate tri-methylated H3 Lys 9 and H3 Lys 36 residue, while it has no activity on mono- and dimethylated residues. JMJD2A demethylation of lysine residues will generate formaldehyde and succinate. It also participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. JMJD2A is a ubiquitously expressed nuclear protein.
JMJD2A (3559D5a)
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JMJD2A (3559D5a): sc-81302 Western Blot analysis of human recombinant JMJD2A fusion protein.
