epitope mapping within an internal region of BTBD4 of human origin
recommended for detection of BTBD4 of mouse, rat and human origin by WB, IP, IF and ELISA; non cross-reactive with other BTBD family members; also reactive with additional species, including equine, bovine and avian
TransCruz reagent for Gel Supershift and ChIP applications, sc-85313 X, 100 µg/0.1 ml
BTBD4 Background Information BTBD4 (BTB/POZ domain-containing protein 4), also known as zinc finger protein 340 (ZNF340) or zinc finger and BTB domain-containing protein 46 (ZBTB46), is a 589 amino acid protein that contains one BTB/POZ domain. The BTB/POZ domain mediates homomeric and heteromeric POZ-POZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD4 may play a role in transcription regulation.
BTBD4 (P-16)
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BTBD4 (P-16): sc-85313. Western blot analysis of BTBD4 expression in HL-60 whole cell lysate.
