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VAC14 (H-261) 抗体: sc-98632 |
| データシート |
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- rabbit polyclonal IgG, 200µg/ml
- epitope corresponding to amino acids 421-681 mapping within an internal region of VAC14 of human origin
- recommended for detection of VAC14 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and avian
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注文情報
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| Species |
遺伝子名 |
Gene ID |
Chromosome Location |
Isoform (mRNA) Accession # |
Protein Accession # |
OMIM™ Number |
| ヒト |
VAC14 |
55697 |
16q22.1 |
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Q08AM6
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604632 |
| マウス |
Vac14 |
234729 |
8 E1 |
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Q80WQ2
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N/A |
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VAC14 Background Information
Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a signaling molecule that exists as a minor component of cell membranes and is essential for the distinguishing of cellular compartments. The synthesis of PI(3,5)P2 is regulated by a number of proteins that are involved in intracellular trafficking and assembly events throughout the cell. VAC14, also known as TAX1BP2 (Tax1-binding protein 2) or TRX, is a 782 amino acid protein that contains six HEAT repeats and exists as part of a regulatory complex with FIG4. Expressed ubiquitously, VAC14 works with FIG4 to control the synthesis of PI(3,5)P2, specifically mediating the activation of PIP5KIII, a kinase involved in the regulation of PI(3,5)P2 activity. The gene encoding VAC14 maps to human chromosome 16, which houses over 900 genes and comprises nearly 3% of the human genome. |
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VAC14 (H-261)
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VAC14 (H-261): sc-98632. Western blot analysis of VAC14 expression in non-transfected: sc-117752 (A) and mouse VAC14 transfected: sc-124533 (B) 293T whole cell lysates. |
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